The Laboratory of Chromatin
Biology and Cancer Epigenetics

Publications

Find our publications and other news items here! You can filter by gene/protein target or cancer type.

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Metabolic Reprogramming by Histone Deacetylase Inhibition Preferentially Targets NRF2-Activated Tumors

Dimitris Karagiannis, Warren Wu, Albert Li, Makiko Hayashi, Xiao Chen, Michaela Yip, Vaibhav Mangipudy, Xinjiang Xu, Francisco J Sanchez-Rivera, Yadira M Soto-Feliciano, Jiangbin Ye, Thales Papagiannakopoulos, Chao Lu

Cell Reports, Jan 23, 2024

Download Download Metabolic Reprogramming by Histone Deacetylase Inhibition Preferentially Targets NRF2-Activated Tumors

Unlocking the Mysteries of Chromatin Biology Through Functional Epigenomics

Ziyang Ye, Alexy A Soshnev, Yadira M Soto-Feliciano

Cancer Research, Dec 15, 2023

Context-Defined Cancer Co-dependency Mapping Identifies a Functional Interplay Between PRC2 and MLL-MEN1 Complex in Lymphoma

Xiao Chen, Yinglu Li, Fang Zhu, Xinjing Xu, Brian Estrella, Manuel A Pazos 2nd, John T McGuire, Dimitris Karagiannis, Varun Sahu, Mustafo Mustafukulov, Claudio Scuoppo, Francisco J Sanchez-Rivera, Yadira M Soto-Feliciano, Laura Pasqualucci, Alberto Ciccia, Jennifer E Amengual, Chao Lu

Nature Communications, Jul 17, 2023

Download Download Context-Defined Cancer Co-dependency Mapping Identifies a Functional Interplay Between PRC2 and MLL-MEN1 Complex in Lymphoma

MLL3 Regulates the Cdkn2a Tumor Suppressor Locus in Liver Cancer

Changyu Zhu, Yadira M Soto-Feliciano, John P Morris, Chun-Hao Huang, Richard P Koche, Yu-Jui Ho, Ana Banito, Chun-Wei Chen, Aditya Shroff, Sha Tian, Geulah Livshits, Chi-Chao Chen, Myles Fennell, Scott A Armstrong, C David Allis, Darjus F Tschaharganeh, Scott W Lowe

eLife, Jun 19, 2023

Download Download MLL3 Regulates the <i>Cdkn2a</i> Tumor Suppressor Locus in Liver Cancer

A Molecular Switch Between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition

Yadira M Soto-Feliciano, Francisco J Sanchez-Rivera, Florian Perner, Douglas W Barrows, Edward R Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X Shirley Liu, Andrei V Krivtsov, Maximiliano Meneses, Elisa de Stanchine, Richard M Stone, Scott A Armstrong, Scott W Lowe, C David Allis

Cancer Discovery, Jan 09, 2023

Download Download A Molecular Switch Between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition

High-Resolution Characterization of Gene Function Using Single-Cell CRISPR Tiling Screen

Lu Yang, Anthony K N Chan, Kazuya Miyashita, Christopher D Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayiki Hoshii, Gang Xiao, Markus Muschen, Jianjun Chen, Scott A Armstrong, Chen-Wei Chen

Nature Communications, Jul 01, 2021

Download Download High-Resolution Characterization of Gene Function Using Single-Cell CRISPR Tiling Screen

Mitochondrial Apoptotic Priming Is a Key Determinant of Cell Fate Upon p53 Restoration

Francisco J Sanchez-Rivera, Jeremy Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova Anthony Letai, Tyler Jacks

PNAS, May 01, 2021

Download Download Mitochondrial Apoptotic Priming Is a Key Determinant of Cell Fate Upon p53 Restoration
Renee Barbosa pipetting into a tube as Yadira Soto-Feliciano looks on

Renee’s Teaching Award

Sep 11, 2024

Our smart and talented grad student Renee Barbosa has been awarded with the Schimmel Fellowship in recognition of her amazing research into the interplay between posttranslational modifications and disease development and progression.

Yadira Soto-Feliciano in the middle of a lecture at an AACR conference

AACR Award

Apr 09, 2024

We would like to recognize Prof. Soto-Feliciano for her excellent lecture at the 2024 American Association for Cancer Research Annual Meeting from April 5-10, 2024. As a recipient of the Gertrude B. Elion Research Award, Prof. Soto-Feliciano spoke about her research on Mechanisms of Gene Regulation by Chromatin Adaptors. Congratulations to Prof. Soto-Feliciano!

Renee’s Preliminary Exam

Apr 04, 2024

On April 4, 2024, Renée Barbosa successfully passed her PhD preliminary exam, officially making her a PhD candidate. Congratulations Renée!

Joe’s Preliminary Exam

Mar 07, 2024

On March 7, 2024, Joseph Ye successfully passed his PhD preliminary exam, officially making him a PhD candidate. Congratulations Joe!

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